Functional Studies Of 5-Carboxyaminoimidazole Ribonucleotide Synthetase And Mutase From Thermotoga Maritima
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چکیده
Functional Studies of 5-Carboxyaminoimidazole Ribonucleotide Synthetaseand Mutase from Thermotoga maritima
منابع مشابه
Novel inhibitors of the bacterial de novo purine biosynthesis enzymes, n5-carboxyaminoimidazole ribonucleotide synthetase and mutase
NOVEL INHIBITORS OF THE BACTERIAL DE NOVO PURINEBIOSYNTHESIS ENZYMES, N-CARBOXYAMINOIMIDAZOLERIBONUCLEOTIDE SYNTHETASE AND MUTASEbyMARIA V FAWAZAugust 2012 Advisor: Dr. Steven M. FirestineMajor: Pharmaceutical SciencesDegree: Master of ScienceAntibiotic resistance has seen a significant increase during the past decade. Theincreasing frequency of the drug-...
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Site-Directed Mutagenesis of Conserved Amino Acids Residues in NCarboxyaminoimidazole Ribonucleotide Mutase & Developing a High-Throughput Screen Assay for the Discovery of NCarboxyaminoimidazole Ribonucleotide Mutase Inhibitors by ZHIWEN SHI July 2014 Advisor: Dr. Steven M. Firestine Major: Pharmaceutical Sciences Degree: Master of Science The de novo purine biosynthesis pathway plays a critic...
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ENZYMOLOGY AND MEDICINAL CHEMISTRY OF N-CARBOXYAMINOIMIDAZOLE RIBONUCLEOTIDE SYNTHETASE:A NOVEL ANTIBACTERIAL TARGETbyHANUMANTHARAO PARITALAAUGUST 2010Advisor: Dr. Steven M. FirestineMajor: Pharmaceutical SciencesDegree: Doctor of PhilosophyN-Carboxyaminoimidazole ribonucleotide synthetase (N-CAIRsynthetase), a key enzyme in microbial de novo purine b...
متن کاملStructural and functional studies of Aspergillus clavatus N(5)-carboxyaminoimidazole ribonucleotide synthetase .
N(5)-Carboxyaminoimidazole ribonucleotide synthetase (N(5)-CAIR synthetase), a key enzyme in microbial de novo purine biosynthesis, catalyzes the conversion of aminoimidazole ribonucleotide (AIR) to N(5)-CAIR. To date, this enzyme has been observed only in microorganisms, and thus, it represents an ideal target for antimicrobial drug development. Here we report the cloning, crystallization, and...
متن کاملIdentification of inhibitors of N5-carboxyaminoimidazole ribonucleotide synthetase by high-throughput screening.
The increasing risk of drug-resistant bacterial infections indicates that there is a growing need for new and effective antimicrobial agents. One promising, but unexplored area in antimicrobial drug design is de novo purine biosynthesis. Recent research has shown that de novo purine biosynthesis in microbes is different from that in humans. The differences in the pathways are centered around th...
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